Informatics Publishing Limited

K. Vijayabhaskar ¹, Macharla Sravanprasad ², Goli. Venkateshwarlu ¹, P. Suvarna Devi ³, K. Hemanth Kumar ⁴, J. Sunil ⁵

Affiliations
1 Venkateshwara Institute of Pharmaceutical Sciences, Nalgonda, Andhra Pradesh-508001, IN
2 GBN Institute of Pharmacy, Ghatkeshar, RR District, Andhra Pradesh-501301, IN
3 Saipranavi College of Pharmacy, Keesara, RR district Andhra Pradesh-501301, IN
4 Shanta College of Pharmacy, Huzurabad, Karimnagar, Andhra Pradesh-505884, IN
5 Anurag College of Pharmacy, Kodada, Nalgonda, Andhra Pradesh-501301, IN

Abstract

The entire wound healing process is a complex series of events that begins at the moment of injury and can continue for months to years. The stages of wound healing are inflammatory phase, proliferation phase, fibroblastic phase and maturation phase. The objective of our study is to investigate wound healing activity of the methanolic leaf extract of of Bauhinia purpurea Linn in rats.. The leaf extract of Bauhinia purpurea (200 mg/kg/day) was evaluated for its wound healing activity in albino rats using excision and incision wound models. Bauhinia purpurea leaf extract treated animals exhibit 83.42 % reduction in wound area when compared to controls which was 76.22 %. The extract treated wounds are found to epithelize faster as compared to controls. Significant (p<0.001) increase in granuloma breaking strength (485±34.64) was observed. The povidone iodine ointment was used as standard.

Keywords

Bauhinia purpurea, Wound Healing, Excision Wound, Incision Wound, Povidone Iodine.

Full Text

     

Venkateshwarlu Goli ¹, Kanakam Vijay Bhaskar ¹, Sravan Prasad Macharla ², Jimmidi Bhaskar ¹, P. Suvarna Devi ³, T. Ramchander ⁴

Affiliations
1 Department of Pharmacognosy, Venkateshwara Institute of Pharmaceutical Sciences, Charlapally, Nalgonda-508001, Andhra Pradesh, IN
2 GBN Institute of Pharmacy, Ghatkesar, RR District, Andhra Pradesh, IN
3 Sai Pranavi College of Pharmacy, Keesara, Ghatkesar, RR District, Andhra Pradesh, IN
4 Mother Theresa College of Pharmacy, NFC Nagar, Ghatkesar, RR District, Andhra Pradesh, IN

Abstract

The present study was carried out to investigate the anti-inflammatory property of petroleum ether, alcoholic and aqueous extracts of Mimosa pudica Linn leaves using experimental animal models. The anti-inflammatory activity of the various extracts was studied based on their effects on carrageenan-induced paw oedema and cotton pellet granuloma in rats. The extracts in dose levels of 50,100 and 200 mg/kg orally were used for anti-inflammatory studies. The ethanol and aqueous extracts of leaves of Mimosa pudica Linn significant (P<0.05) anti-inflammatory activities in a dose-dependent manner to that of standard drug indomethacin, while petroleum ether extract exhibit minimum inhibitory effect in carageenan induced hind paw oedema and cotton pellet granuloma in rats. All the doses used when compared to the control group. The results obtained indicate that the crude leaf extracts of mimosa pudica possess potent anti-inflammatory by supporting the folkloric usage of the plant to treat various inflammatory conditions.

Keywords

Mimosa pudica, Anti-Inflammatory Activity, Rat Paw Oedema, Carrageenan Induced Inflammation.

Full Text